Buffalo

Before the 17th century, the region was inhabited by nomadic Paleo-Indians who were succeeded by the Neutral, Erie, and Iroquois nations. In the early 17th century, the French began to explore the region. In the 18th century, Iroquois land surrounding Buffalo Creek was ceded through the Holland Land Purchase, and a small village was established at its headwaters. Buffalo was selected as the terminus of the Erie Canal in 1825, which led to its incorporation in 1832 and stimulated its growth as the primary inland port between the Great Lakes and Atlantic Ocean. Transshipment made Buffalo the world's largest grain port in that era.