Santo Domingo Tehuantepec

The city is still the center of Zapotec culture in the Isthmus of Tehuantepec and is the second largest in the region. The city is known for its women and their traditional dress, which was adopted by Frida Kahlo. Tehuantepec has a reputation for being a matriarchal society. Women dominate the local markets and are known to taunt men. However, political power is still the domain of men.

The city experienced a short economic boom in the early 20th century related to a rail line that was built linking the two oceans, but it was soon eclipsed by the Panama Canal. The project, however, has revived since 2018, as the Mexican government has worked on the rehabilitation of the line and other projects related to it, in a project known as the Interoceanic Corridor of the Isthmus of Tehuantepec.